eHealth system with ISFET-based immunosensor for heart failure biomarker detection in saliva

“eHealth system with ISFET-based immunosensor for heart failure biomarker detection in saliva”

Albert Alcacer, Hamdi Ben Halima, Marie Hangouet, Hamid ElAissari, Abdelhamid Errachid, Joan Bausells

13th Spanish Conference on Electron Devices.
2021 IEEE (114-116)

ABSTRACT
Heart failure is a chronic condition that sorely affects the worldwide population withhugehealthandeconomic costs. The purpose of this research istopresentanISFET-based immunosensor sensible to low concentrations of TNF-α biomarker in saliva, a protein related with the severity state of heart failure patients,togetherwithaproof-of-conceptIoT-based user-centered health ecosystem, aiming to reduce hospital-centered associated costs and improving patient monitoring. The immunosensor presents a low limit ofdetection of 5pg/mL, with good cross-selectivity versus other saliva biomarkers, using a low cost and short run-time detection technique, optimal for its implementation in a distributed monitoring system.